Time-dependent genetic effects on gene expression implicate aging processes
نویسندگان
چکیده
منابع مشابه
Genetic Effects on Aging
This volume contains papers presented at a conference held at the Jackson Laboratory in 1976 under the auspices of the National Foundation. The papers deal with several extremely interesting observations and ideas that support the notion that senescence is genetically controlled. Even if the reader has not been previously acquainted with the literature on aging, this book will provide a readabl...
متن کاملCommentary: aging, differentiation-dependent gene expression, and fat cell function.
THE key finding in this interesting article by Hotta and colleagues, "Age-Related Adipose Tissue mRNA Expression ofADDlISREBPl, PPARy, Lipoprotein Lipase, and GLUT4 Glucose Transporter in Rhesus Monkeys" (pp. B 183-B188), is that aging is associated with declines in expression of certain transcription factors that regulate preadipocyte differentiation and fat cell function in whole fat tissue f...
متن کاملConvergent genetic and expression data implicate immunity in Alzheimer's disease.
BACKGROUND Late-onset Alzheimer's disease (AD) is heritable with 20 genes showing genome-wide association in the International Genomics of Alzheimer's Project (IGAP). To identify the biology underlying the disease, we extended these genetic data in a pathway analysis. METHODS The ALIGATOR and GSEA algorithms were used in the IGAP data to identify associated functional pathways and correlated ...
متن کاملTime-Dependent Effects of Localized Inflammation on Peripheral Clock Gene Expression in Rats
Many aspects of the immune system, including circulating cytokine levels as well as counts and function of various immune cell types, present circadian rhythms. Notably, the mortality rate of animals subjected to high doses of lipopolysaccharide is dependent on the time of treatment. In addition, the severity of symptoms of various inflammatory conditions follows a daily rhythmic pattern. The m...
متن کاملTime- and dose-dependent effects of curcumin on gene expression in human colon cancer cells
BACKGROUND: Curcumin is a spice and a coloring food compound with a promising role in colon cancer prevention. Curcumin protects against development of colon tumors in rats treated with a colon carcinogen, in colon cancer cells curcumin can inhibit cell proliferation and induce apoptosis, it is an anti-oxidant and it can act as an anti-inflammatory agent. The aim of this study was to elucidate ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Genome Research
سال: 2017
ISSN: 1088-9051,1549-5469
DOI: 10.1101/gr.207688.116